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Protein Creatinine Ratio Formula:
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The Protein Creatinine Ratio (PCR) is a clinical measurement used to estimate protein excretion in urine. It provides a more accurate assessment of proteinuria than random urine protein measurements and helps in monitoring kidney function and diagnosing renal diseases.
The calculator uses the standard PCR formula:
Where:
Explanation: The ratio normalizes protein excretion to creatinine excretion, providing a more reliable measure of proteinuria that accounts for variations in urine concentration.
Details: PCR is crucial for screening, diagnosing, and monitoring proteinuria in various kidney diseases. It helps in assessing the severity of kidney damage, guiding treatment decisions, and monitoring response to therapy.
Tips: Enter both protein and creatinine values in mg/dL. Both values must be positive numbers. The calculator will automatically compute the PCR ratio in mg/g.
Q1: What is a normal PCR value?
A: Normal PCR is typically less than 150 mg/g. Values between 150-500 mg/g indicate microalbuminuria, while values above 500 mg/g suggest macroalbuminuria.
Q2: Why multiply by 100 in the formula?
A: Multiplying by 100 converts the ratio to milligrams per gram (mg/g), which is the standard unit for reporting PCR results.
Q3: When should PCR be measured?
A: PCR is typically measured in random urine samples. First morning void is preferred as it provides the most consistent results.
Q4: Are there limitations to PCR measurement?
A: PCR may be less accurate in individuals with very low or very high muscle mass, as creatinine excretion correlates with muscle mass.
Q5: How does PCR compare to 24-hour urine collection?
A: PCR provides a reliable estimate of protein excretion that correlates well with 24-hour urine protein measurements, making it a convenient alternative.