1. What is Protein Creatinine Ratio?

The Protein Creatinine Ratio (PCR) is a simple mass ratio used to estimate protein excretion in urine. It's calculated by dividing urine protein (in milligrams) by urine creatinine (in milligrams) from the same urine sample.

2. How Does the Calculator Work?

The calculator uses the PCR equation:

Where:

• Urine Protein — Protein content in urine sample (mg)
• Urine Creatinine — Creatinine content in urine sample (mg)

Explanation: This ratio corrects for variations in urine concentration, providing a more reliable measure of protein excretion than protein concentration alone.

3. Importance of PCR Calculation

Details: PCR is used to screen for and monitor proteinuria, which is an important marker of kidney damage. It's particularly useful for detecting and monitoring diabetic nephropathy and other kidney diseases.

4. Using the Calculator

Tips: Enter both urine protein and urine creatinine values in milligrams. Both values must be greater than zero for accurate calculation.

5. Frequently Asked Questions (FAQ)

Q1: What is a normal PCR value?
A: Normal PCR is typically less than 0.2 mg/mg. Values between 0.2-3.5 mg/mg suggest microalbuminuria, while values above 3.5 mg/mg indicate overt proteinuria.

Q2: Why use PCR instead of 24-hour urine collection?
A: PCR provides a reliable estimate of protein excretion from a single urine sample, avoiding the inconvenience and potential errors of 24-hour urine collection.

Q3: When should PCR be measured?
A: First morning urine samples are preferred as they provide the most consistent results. Random samples can also be used but may be less reliable.

Q4: Are there limitations to PCR?
A: PCR may be less accurate in people with very high or very low muscle mass, as creatinine excretion correlates with muscle mass.

Q5: How often should PCR be monitored?
A: For patients with kidney disease or diabetes, PCR is typically monitored annually or more frequently if abnormal values are detected.